Chronic Myelogenous Leukemia

CML in the bloodChronic Myelogenous Leukemia is more common in adults than children and is acquired rather than inherited, although the Philadelphia chromosome has been implicated in CML cases. Patients with CML tire easily, are pale, have enlarged spleens, and often have excessive weight loss.

Incidence: CML affects about 4,000- 4,600 people each year in the U.S. (Robien and Ulrich, 2003).

Prevalence in children: In children under 20, CML represents only about 2.6% of leukemia cases. From ages 1-10, one in one million children gets CML. By age 50, the rate is nearly two in 100,000 people, and at age 80, 1 in 10,000 people develop CML (Leukemia and Lymphoma Society, 2005).

Average age at onset: The average age of CML patients is between 45 and 55 years old (Robien and Ulrich, 2003).

Specific risk factors: Unlike the other three major types of leukemia, CML is caused by a translocation on the “Philadelphia chromosome” in stem cells and the blood cells they produce. The cause of the breakage that allows the translocation is not known. In some patients, it is caused by exposure to radiation. The altered chromosome is shorter than normal, and produces abnormally lengthened proteins that do not function correctly. The damaged stem cell is able to grow and survive better than other bone marrow cells and caues an uncontrolled and excessive amount of white blood cells. The white blood cells are usually able to function normally (Leukemia and Lymphoma Society, 2005).


References Cited

Created by Shannon McGlauflin, Jolene Munger, and Rebecca Nelson, 2005.